Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 25201101
Gene Name FPR1
Condition Endometriosis
Association Associated
Population size 28
Population details 28 (18 women with abdominal wall endometriosis,10 women without endometriosis)
Age 20- 45 yrs
Sex Female
Associated genes ANXA1, CMA1, FPR1, TPSAB1
The intricate role of mast cell proteases and the annexin A1-FPR1 system in abdominal wall endometriosis.

J Mol Histol. 2015 Feb;46(1):33-43. doi: 10.1007/s10735-014-9595-y. Epub 2014 Sep

Paula, Rubens Jr| Oliani, Antonio H| Vaz-Oliani, Denise C M| D'Avila, Solange C G P| Oliani, Sonia M| Gil, Cristiane D

Laboratorio de Imunomorfologia, Departamento de Biologia, Universidade Estadual Paulista (UNESP), Sao Jose do Rio Preto, Sao Paulo, 15054-000, Brazil.

Endometriosis is a continuous and progressive disease with a poorly understood aetiology, pathophysiology and natural history. This study evaluated the histological differences between eutopic and ectopic endometria (abdominal wall endometriosis) and the expression of mast cell proteases (tryptase and chymase), annexin A1 (ANXA1) and formyl peptide receptor 1 (FPR1). Ectopic endometrium from 18 women with abdominal wall endometriosis and eutopic endometrium from 10 women without endometriosis were obtained. The endometrial samples were analysed by histopathology, immunohistochemistry and ultrastructural immunogold labeling to determine mast cell heterogeneity (tryptase and chymase positive cells) and the expression levels of ANXA1 and FPR1. Histopathological analysis of the endometriotic lesions showed a glandular pattern of mixed differentiation and an undifferentiated morphology with a significant influx of inflammatory cells and a change in mast cell heterogeneity, as evidenced by a significant increase in the number of chymase-positive cells and endogenous chymase expression. The undifferentiated glandular pattern of endometriotic lesions was positively associated with a marked increase and co-localization of ANXA1 and FPR1 in the epithelial cells. In conclusion, the co-upregulated expression of mast cell chymase and ANXA1-FPR1 system in ectopic endometrium suggests their involvement in the development of endometriotic lesions.

Mesh Terms: Abdominal Wall/pathology| Adult| Annexin A1/genetics/*metabolism| Endometriosis/*metabolism/*pathology| Endometrium/metabolism/pathology| Female| Gene Expression| Humans| Immunohistochemistry| Mast Cells/*enzymology/pathology| Middle Aged| Muco